Please wait...

RoboLQ Frequently asked questions (FAQ)

What is the minimum and maximum volumes RoboLQ can dispense?

Minimum- 1ul

Maximum- 1200ul (per dispense)

Multiple dispenses can be used for larger volume applications

What is the maximum particle size in suspension that will still flow through RoboLQ?

736 Micron

What are the minimum & maximum viscosity ranges that can flow through RoboLQ?

This will change depending on the tips (pore size / dead volume) and the pipette head used. The water bath will change the temperature of the formulation, and therefore (for the filler materials we are using for RoboLQ) the viscosity. With the smaller MAX8x200, we have observed good results with methanol (@ 0.50 cP) and an 80% glycerol solution (@ 80 cP). The tips used for testing have a smaller pore size than the standard RoboLQ D1200 tips. We would expect this range to shift up.

What is the standard loss per batch with the RoboLQ Series?

On the Lab configuration, the only loss is what is not salvageable from the seahorse reservoirs. ( ie. whatever material sticks to the walls of the reservoir) On the Blend and Thermal models, the dead loss is roughly 1% on a standard batch size of 2L. (Roughly 25ml of fluid) This number can be reduced by shortening the length of the tubing as well as utilizing a larger size reservoir( ie 5L reservoir) However, a smaller reservoir will reduce the loss of material that sticks to the inner walls.

What is the average batch cycle time per capsule size?

What is the recommended purge time to clear the lines on the Blend & Thermal models?

The volume of the reservoir on the bed and the tubing will circulate within a few seconds however, we recommend letting the purge cycle run for up to five minutes to ensure that the formulation has been evacuated or put into a solution (if using a solvent)

How does RoboLQ guarantee accurate and precise dosage?

RoboLQ is calibrated using a protocol that conforms to ISO:8655-6 gravimetric methods for the determination of measurement error.

This method covers the performance on a piston-operated volumetric apparatus when used with analytical grade laboratory water.

There are a few items to consider with the RoboLQ system:

We do not guarantee performance with any substance other than water, and it is the responsibility of the individual user to determine the performance of the device with a given test fluid, and whether the performance observed is suitable for the application.

The verification screen that we built is the best way forward from an accuracy standpoint. TCG cannot know what new formulations our customers will use, and each one of these will require tweaks to the liquid handling behavior to achieve good and consistent results.

To which certifications standards does RoboLQ conform?

RoboLQ is manufactured to TUV Rhineland Standards, not cGMP standards. GMP standards are FDA regulated standards, and we do not manufacture FDA listed instruments. TCG conforms to ISO:9001 standards for quality control. It is the onus of the client to submit their formulation to the FDA for approval, at which point they can receive cGMP certification for their machine and application.

Can RoboLQ be used in Clinical Trials?

RoboLQ can be used in stages 1-5 of The Drug Development Process Clinical Research Phase Studies

Phase 1

Patients: 20 to 100 healthy volunteers or people with the disease/condition.

Length of Study: Several months

Purpose: Safety and dosage

Approximately 70% of drugs move to the next phase

Phase 2

Patients: Up to several hundred people with the disease/condition.

Length of Study: Several months to 2 years

Purpose: Efficacy and side effects

Approximately 33% of drugs move to the next phase

Phase 3

Patients: 300 to 3,000 volunteers who have the disease or condition

Length of Study: 1 to 4 years

Purpose: Efficacy and monitoring of adverse reactions

Approximately 25-30% of drugs move to the next phase

Phase 4

Patients: Several thousand volunteers who have the disease/condition

Purpose: Safety and efficacy

See link below for more details

Are there any fill materials that cannot be used in RoboLQ

1) Oxygen sensitive materials (unless RoboLQ is installed in a lab hood)

2) Fill materials with adverse reactions to polypropylene.

Cleanability and Cross Contamination Prevention

The removable components of RoboLQ are all autoclavable and can

withstand most laboratory solvents (methanol / propanol / detergents). The exception being the TCG capsule rack, since the nylon inserts will absorb moisture and distort.

RoboLQ uses virgin polypropylene disposable tips to isolate liquid handling operations from one another.

We recommend the use of mild cleaning solvents like methanol or propanol, and up to a 10% bleach solution or detergent for decontamination. The contact materials of the system include:

Fluid contact

  1. Polypropylene (tips / seahorse racks / BLEND & THERMAL tubing connections at the bottle cap)
  2. Stainless steel (BLEND & THERMAL tubing connections at the reservoir)
  3. Pharmed BPT (BLEND & THERMAL tubing)
  4. Teflon PTFE (BLEND & THERMAL bottle cap)
  5. Borosilicate glass (BLEND & THERMAL bottles)
  6. PEEK (BLEND & THERMAL reservoir)
  7. Potential vapor contact
  8. Stainless steel (pistons barrels)
  9. PEEK (tip holders)
  10. ULTEM (tip holder support)
  11. Polybutylene terephthalate (pipette head covers)
  12. Polyethylene terephthalate (piston plungers)

What is the recommended service regimen for the RoboLQ system (Calibration, Preventative Maintenance and Lubrication)

Alignment of the system (by running the alignment protocol) need only be run after the instrument is moved. The alignment protocol is run during preventative maintenance as well.

Preventative maintenance (XYZ axes)

  1. Preventative maintenance involves a general cleaning of the machine and a clean regrease of the Z drive. This helps prevent interference with debris that could lead to the instrument stalling during operation.
  2. The instrument should not require additional service the XYZ components, but depending on use, the pipette heads may require service more than once a year.

Preventative maintenance (pipette heads)

  1. Preventative maintenance or calibration of the pipette heads ensures that they are still operating within manufacturer specifications. In the case of our customers’ applications, this may be of little use, as they may wish to perform their own verification using their unique formulation.
  2. Typical service intervals include service every 3, 6 and 12 months with 12 months being the most common.
  3. TCG standard service of the pipette heads includes performing a leak test on all channels, followed by gravimetric calibration of the pipette head.

What are RoboLQ’s operation limitations?

There are no limits on the duty cycle of RoboLQ within most standard 8-hour shift applications.

Are there any environmental considerations to keep in mind when operating RoboLQ?

Temperature and humidity may affect volumetric the performance of the instrument, but the severity of the effect will depend on the formulation. Here again, the verification screen located in the settings tab will provide the user a method to calibrate to their local conditions. Environmental conditions will have to meet the following criteria to ensure the safe operation of RoboLQ instrument.

Indoor use

  1. Altitude: up to 2000 m
  2. Temperature range: 5°–40°C
  3. Humidity: Maximum relative humidity 80% for temperatures up to 31°C, decreasing linearly to 50% relative humidity at 40°C

What are the average kilowatts per hour RoboLQ will use?

These values are taken from our EMC compliance tests and represent a more rigorous regimen of use compared to most capsule filling protocols.

At peak usage (tip installation or eject) the system is using 126 Watts

Standard power usage (RMS) is 41 Watts

RoboLQ itself is rated at 150 Watts

We would expect to see ~0.041kWh as the rate of power used in a typical application. However, the instrument could conceivably draw up to 150 Watts for short periods.

Wear and Tear to Consider


  • Change tips after use
  • Change reservoirs as needed
    • Polypropylene can be washed and reused and decontaminated with a mild solvent, detergent or 10% bleach solution
    • Autoclaving is possible at temperatures of 121°C @15psi


  • Change tubing every 750 hours of operation
  • Case studies indicate that 1000 hours of operation is possible, but we would recommend changing the tubing before it ruptures rather than after.


  • Change the water daily
  • Wash the bath daily

Where can I purchase replacement consumables & accessories?

A full list of products is available in the RoboDose Formulations in-app store. Purchase replacement parts, consumables, capsules and accessories with one touch.

Do you ship to Canada and International?

Yes, we’ll ship your package anywhere that can accept deliveries.

Do you have technical support?

Of course! Our friendly and knowledgeable technical support team is available to answer your questions 24/7/365.