Maximum- 1200ul (per dispense)
Multiple dispenses can be used for larger volume applications
This will change depending on the tips (pore size / dead volume) and the pipette head used. The water bath will change the temperature of the formulation, and therefore (for the filler materials we are using for RoboLQ) the viscosity. With the smaller MAX8x200, we have observed good results with methanol (@ 0.50 cP) and an 80% glycerol solution (@ 80 cP). The tips used for testing have a smaller pore size than the standard RoboLQ D1200 tips. We would expect this range to shift up.
On the Lab configuration, the only loss is what is not salvageable from the seahorse reservoirs. ( ie. whatever material sticks to the walls of the reservoir) On the Blend and Thermal models, the dead loss is roughly 1% on a standard batch size of 2L. (Roughly 25ml of fluid) This number can be reduced by shortening the length of the tubing as well as utilizing a larger size reservoir( ie 5L reservoir) However, a smaller reservoir will reduce the loss of material that sticks to the inner walls.
The volume of the reservoir on the bed and the tubing will circulate within a few seconds however, we recommend letting the purge cycle run for up to five minutes to ensure that the formulation has been evacuated or put into a solution (if using a solvent)
RoboLQ is calibrated using a protocol that conforms to ISO:8655-6 gravimetric methods for the determination of measurement error.
This method covers the performance on a piston-operated volumetric apparatus when used with analytical grade laboratory water.
There are a few items to consider with the RoboLQ system:
We do not guarantee performance with any substance other than water, and it is the responsibility of the individual user to determine the performance of the device with a given test fluid, and whether the performance observed is suitable for the application.
The verification screen that we built is the best way forward from an accuracy standpoint. TCG cannot know what new formulations our customers will use, and each one of these will require tweaks to the liquid handling behavior to achieve good and consistent results.
RoboLQ is manufactured to TUV Rhineland Standards, not cGMP standards. GMP standards are FDA regulated standards, and we do not manufacture FDA listed instruments. TCG conforms to ISO:9001 standards for quality control. It is the onus of the client to submit their formulation to the FDA for approval, at which point they can receive cGMP certification for their machine and application.
RoboLQ can be used in stages 1-5 of The Drug Development Process Clinical Research Phase Studies
Patients: 20 to 100 healthy volunteers or people with the disease/condition.
Length of Study: Several months
Purpose: Safety and dosage
Approximately 70% of drugs move to the next phase
Patients: Up to several hundred people with the disease/condition.
Length of Study: Several months to 2 years
Purpose: Efficacy and side effects
Approximately 33% of drugs move to the next phase
Patients: 300 to 3,000 volunteers who have the disease or condition
Length of Study: 1 to 4 years
Purpose: Efficacy and monitoring of adverse reactions
Approximately 25-30% of drugs move to the next phase
Patients: Several thousand volunteers who have the disease/condition
Purpose: Safety and efficacy
See link below for more details http://www.fda.gov/ForPatients/Approvals/Drugs/ucm405622.htm#Clinical_Research_Phase_Studies
1) Oxygen sensitive materials (unless RoboLQ is installed in a lab hood)
2) Fill materials with adverse reactions to polypropylene.
The removable components of RoboLQ are all autoclavable and can
withstand most laboratory solvents (methanol / propanol / detergents). The exception being the TCG capsule rack, since the nylon inserts will absorb moisture and distort.
RoboLQ uses virgin polypropylene disposable tips to isolate liquid handling operations from one another.
We recommend the use of mild cleaning solvents like methanol or propanol, and up to a 10% bleach solution or detergent for decontamination. The contact materials of the system include:
Alignment of the system (by running the alignment protocol) need only be run after the instrument is moved. The alignment protocol is run during preventative maintenance as well.
Preventative maintenance (XYZ axes)
Preventative maintenance (pipette heads)
There are no limits on the duty cycle of RoboLQ within most standard 8-hour shift applications.
Temperature and humidity may affect volumetric the performance of the instrument, but the severity of the effect will depend on the formulation. Here again, the verification screen located in the settings tab will provide the user a method to calibrate to their local conditions. Environmental conditions will have to meet the following criteria to ensure the safe operation of RoboLQ instrument.
These values are taken from our EMC compliance tests and represent a more rigorous regimen of use compared to most capsule filling protocols.
At peak usage (tip installation or eject) the system is using 126 Watts
Standard power usage (RMS) is 41 Watts
RoboLQ itself is rated at 150 Watts
We would expect to see ~0.041kWh as the rate of power used in a typical application. However, the instrument could conceivably draw up to 150 Watts for short periods.
A full list of products is available in the RoboDose Formulations in-app store. Purchase replacement parts, consumables, capsules and accessories with one touch.
Yes, we’ll ship your package anywhere that can accept deliveries.
Of course! Our friendly and knowledgeable technical support team is available to answer your questions 24/7/365.